Branford River Resort & Spa 249 East Main Street Branford, CT 06405 phone: (203)-488-5902 email: inquiries@branfordriverspa.com Directions to Branford River Resort & Spa From I-95 North - Take Exit 55. At end of ramp take a left. Go approximately one mile and you will see the Spa on your left hand side. From I-95 South - Take Exit 55. At end of ramp take a right. Go approximately one mile and you will see the Spa on your left hand side.